Dr Yusuke Nishimura is a Postdoctoral Research Associate in Muscle Proteomics within the Cellular & Molecular Physiology of Lifelong Health (CaMP-LH) research group at Liverpool John Moores University. His research focuses on the molecular and cellular mechanisms regulating skeletal muscle protein turnover and mass in both health and disease, with key contributions in skeletal muscle aging and facioscapulohumeral muscular dystrophy (FSHD) through proteomics-based approaches.
Languages
Japanese
English
Degrees
2022, University of Birmingham, United Kingdom, PhD
2018, University of Birmingham, United Kingdom, MRes
2016, Ritsumeikan University, Japan, BSc
Certifications
2024, AdvanceHE, Associate Fellowship (AFHEA)
2024, SEDA, SEDA Recognised for Supporting Learning
Postgraduate training
Research Associate in Muscle Proteomics, United Kingdom, Liverpool John Moores University, 2022 - present
Highlighted publications
Nishimura Y, Bittel AJ, Stead CA, Chen Y-W, Burniston JG. 2023. Facioscapulohumeral muscular dystrophy is associated with altered myoblast proteome dynamics Molecular & Cellular Proteomics, 22 DOI Author Url Publisher Url Public Url
Nishimura Y, Chunthorng-Orn J, Lord S, Musa I, Dawson P, Holm L, Lai YC. 2022. Ubiquitin E3 ligase Atrogin-1 protein is regulated via the rapamycin-sensitive mTOR-S6K1 signaling pathway in C2C12 muscle cells American Journal of Physiology: Cell Physiology, 323 :C215-C225 DOI Author Url Publisher Url Public Url
Nishimura Y, Jensen M, Bülow J, Thomsen TT, Arimitsu T, van Hall G, Fujita S, Holm L. 2022. Co-ingestion of cluster dextrin carbohydrate does not increase exogenous protein-derived amino acid release or myofibrillar protein synthesis following a whole-body resistance exercise in moderately trained younger males: a double-blinded randomized controlled crossover trial European Journal of Nutrition, DOI Author Url Publisher Url Public Url
Nishimura Y, Højfeldt G, Breen L, Tetens I, Holm L. 2021. Dietary protein requirements and recommendations for healthy older adults: a critical narrative review of the scientific evidence. Nutrition research reviews, :1-17 DOI Author Url Publisher Url Public Url
Nishimura Y, Musa I, Holm L, Lai YC. 2021. Recent advances in measuring and understanding the regulation of exercise-mediated protein degradation in skeletal muscle American Journal of Physiology: Cell Physiology, 321 :C276-C287 DOI Author Url Publisher Url Public Url
preprint
Nishimura Y, Bittel A, Jagan A, Chen Y-W, Burniston J. 2025. Proteomic profiling uncovers sexual dimorphism in the muscle response to wheel running exercise in the FLExDUX4 murine model of facioscapulohumeral muscular dystrophy. DOI Author Url Publisher Url
Jagan A, Nishimura Y, Donnovan T, Burniston JG. 2025. Non-targeted Analysis of Extracellular Vesicle-Enriched Plasma Proteome between Early and Late Rugby Playing Career Cold Spring Harbor Laboratory DOI Publisher Url
Nishimura Y, Bittel A, Stead C, Chen Y-W, Burniston J. 2022. Facioscapulohumeral muscular dystrophy is associated with altered myoblast proteome dynamics bioRxiv DOI Publisher Url
Nishimura Y, Musa I, Dawson P, Holm L, Lai Y-C. 2021. Ubiquitin E3 ligases Atrogin-1 and MuRF1 protein contents are differentially regulated in the rapamycin-sensitive mTOR-S6K1 signaling pathway in C2C12 myotubes bioRxiv DOI Publisher Url
Journal article
Nishimura Y, Bittel AJ, Stead CA, Chen Y-W, Burniston JG. 2023. Facioscapulohumeral muscular dystrophy is associated with altered myoblast proteome dynamics Molecular & Cellular Proteomics, 22 DOI Author Url Publisher Url Public Url
Nishimura Y, Chunthorng-Orn J, Lord S, Musa I, Dawson P, Holm L, Lai YC. 2022. Ubiquitin E3 ligase Atrogin-1 protein is regulated via the rapamycin-sensitive mTOR-S6K1 signaling pathway in C2C12 muscle cells American Journal of Physiology: Cell Physiology, 323 :C215-C225 DOI Author Url Publisher Url Public Url
Nishimura Y, Jensen M, Bülow J, Thomsen TT, Arimitsu T, van Hall G, Fujita S, Holm L. 2022. Co-ingestion of cluster dextrin carbohydrate does not increase exogenous protein-derived amino acid release or myofibrillar protein synthesis following a whole-body resistance exercise in moderately trained younger males: a double-blinded randomized controlled crossover trial European Journal of Nutrition, DOI Author Url Publisher Url Public Url
Nishimura Y, Højfeldt G, Breen L, Tetens I, Holm L. 2021. Dietary protein requirements and recommendations for healthy older adults: a critical narrative review of the scientific evidence. Nutrition research reviews, :1-17 DOI Author Url Publisher Url Public Url
Nishimura Y, Musa I, Holm L, Lai YC. 2021. Recent advances in measuring and understanding the regulation of exercise-mediated protein degradation in skeletal muscle American Journal of Physiology: Cell Physiology, 321 :C276-C287 DOI Author Url Publisher Url Public Url
Edwards SJ, Smeuninx B, McKendry J, Nishimura Y, Luo D, Marshall RN, Perkins M, Ramsay J, Joanisse S, Philp A, Breen L. 2020. High-dose leucine supplementation does not prevent muscle atrophy or strength loss over 7 days of immobilization in healthy young males American Journal of Clinical Nutrition, 112 :1368-1381 DOI Author Url Publisher Url
Højfeldt G, Nishimura Y, Mertz K, Schacht SR, Lindberg J, Jensen M, Hjulmand M, Lind MV, Jensen T, Jespersen AP, Reitelseder S, Tetens I, Holm L. 2020. Daily protein and energy intake are not associated with muscle mass and physical function in healthy older individuals—a cross-sectional study Nutrients, 12 :1-16 DOI Author Url Publisher Url
Luo D, Edwards S, Smeuninx B, McKendry J, Nishimura Y, Perkins M, Philp A, Joanisse S, Breen L. 2020. Immobilization leads to alterations in intracellular phosphagen and creatine transporter content in human skeletal muscle American Journal of Physiology - Cell Physiology, 318 :C34-C44 DOI Author Url Publisher Url
Smeuninx B, Nishimura Y, McKendry J, Limb M, Smith K, Atherton PJ, Breen L. 2019. The effect of acute oral phosphatidic acid ingestion on myofibrillar protein synthesis and intracellular signaling in older males Clinical Nutrition, 38 :1423-1432 DOI Author Url Publisher Url
Yoshii N, Sato K, Ogasawara R, Nishimura Y, Shinohara Y, Fujita S. 2018. Effect of mixed meal and leucine intake on plasma amino acid concentrations in young men Nutrients, 10 DOI Author Url Publisher Url
Other
Nishimura Y, Hojfeldt G, Breen L, Tetens I, Holm L. 2023. Erratum: Dietary protein requirements and recommendations for healthy older adults: a critical narrative review of the scientific evidence (Nutrition Research Reviews FirstView (2021) (1-17) DOI: 10.1017/S0954422421000329) Nutrition Research Reviews, 36 :175 DOI Author Url Publisher Url
Conference publication
Nishimura Y, Hojfeldt G, Schacht SR, Mertz K, Hjulmand M, Reitelseder S, Lind MV, Tetens I, Holm L. 2020. Impact of daily protein and energy intake and distribution on muscle mass and strength in Danish older individuals-The CALM study PROCEEDINGS OF THE NUTRITION SOCIETY, 79 :E103-E103 DOI Publisher Url
Edwards S, Smeuninx B, McKendry J, Nishimura Y, Perkins M, Ramsay J, Joanisse S, Philp A, Breen L. 2020. Leucine Supplementation Does Not Attenuate Metabolic Or Functional Declines Following 7-days Of Unilateral Lower-limb Immobilisation. MEDICINE & SCIENCE IN SPORTS & EXERCISE, 52 :507-507
Edwards S, Smeuninx B, McKendry J, Nishimura Y, Perkins M, Ramsay J, Joanisse S, Philp A, Breen L. Leucine Supplementation Does Not Attenuate Metabolic Or Functional Declines Following 7-days Of Unilateral Lower-limb Immobilisation Medicine and Science in Sports and Exercise, The American College of Sports Medicine 52 :507-507 DOI Author Url Publisher Url
Kido K, Ato S, Nishimura Y, Yokokawa T, Sato K, Fujita S. Chronic Resistance Training-Induced Increase in Insulin-Stimulated Akt Activation and GLUT4 Translocation Is Associated with APPL1 Expression in Skeletal Muscle of Type 2 Diabetic Rat Diabetes, 77th Scientific Sessions of the American-Diabetes-Association 66 :A191-A191 Author Url
Jagan A, Nishimura Y, Close G, Burniston J. Non-targeted analysis of the plasma proteome between early and late rugby playing career BASES Student Conference 2024 1 DOI Author Url Publisher Url
External committees:
UKRI, BBSRC 24RM3 Committee D. 2025
eLife, eLife Ambassador, https://elifesciences.org/inside-elife/2db39138/elife-community-ambassadors-107-early-career-researchers-join-the-programme. 2025
UKRI BBSRC, A member of the Pool of Experts, Pool of Experts. 2024
Conference presentation:
Oral presentation, King's College London, UK, 12th London Proteomics Discussion Group meeting, Proteomic insights into sex-specific exercise responses in FLExDUX4 mice, https://www.londonproteomics.co.uk/. 2025
Poster presentation, Liverpool, UK, Healthy Muscle Ageing Conference, Dynamic proteome profiling uncovers age-related impairments in proteostasis in human skeletal muscle. 2023
Oral presentation, Dublin, Ireland, 13th European Nutrition Conference, Impact of daily protein and energy intake and distribution on muscle mass and strength in Danish older individuals-The CALM study. 2019
Research Grants Awarded:
Grant value (£): 300, The Biochemical Society, Online Attendance Grant. 2024
Grant value (£): 1500, The Physiological Society, Unlocking Futures Fund. 2023
Duration of research project: 1 year, Grant value (£): 71,426 USD, FSHD Society, Prof Jatin Burniston, Dr Yi-Wen Chen, Dr Adam Bittel, Deciphering proteomic signatures of sexual dimorphism in FSHD. 2023
Grant value (£): 750, The Physiological Society, Professional Development Award. 2023
Duration of research project: 1 year, Grant value (£): 440,000 JPY, Institute for Food and Health Science, Yazuya Co., Ltd, Dr Jun Yasuda, Dr Akiko Kamei, Dr Takahiro Yoshizaki, Prof Satoshi Fujita, Interaction between energy and protein intake on resistance exercise-induced muscle hypertrophy –Systematic review and meta-analysis. 2020
Grant value (£): 400 USD, Vanderbilt University, Scholarship for attendance to the 2019 Isotope Tracers in Metabolic Research: Principles and Practice of Kinetic Analysis (12th Annual Course). 2019
Grant value (£): 500, The Physiological Society, Travel Grant. 2019
Teaching qualification:
Associate Fellowship, AdvanceHE (AFHEA). 2024
SEDA Recognised for Supporting Learning, SEDA. 2024
3is – Information, Ideas & Insights Programme, The LJMU Teaching and Learning Academy. 2023
Media Coverage:
Unlocking the unparalleled insights of omic analysis 2024
ASBMB TODAY - Journal News 2024
Muscular Dystrophy UK, News, Blogs, and Stories 2023
Muscular Dystrophy UK, News, Blogs, and Stories 2023
Award:
Liverpool John Moores University, Vice Chancellor's Award for Excellence - Rising Star (Faculty of Science Winner). 2023
The Nutrition Society, Nutrition Research Reviews - Paper of the Month for April, https://www.cambridge.org/core/blog/2022/04/26/dietary-protein-requirements-and-recommendations-why-is-it-so-complex/. 2022
Other Professional Activity:
FSHD UK, Research Strategy Group, https://fshduk.com/. 2023
The Research Communications Group (Muscular Dystrophy UK). 2022
Membership of professional bodies:
British Society for Research on Ageing (BSRA), Full Member. 2023
American Physiological Society, Postdoctoral Membership.
The American Society for Mass Spectrometry, Regular Member.
The Biochemical Society, Early Career Membership.
The Dunhill Medical Trust, Academy Member.
The Physiological Society, Full Membership.
Editorial boards:
Editorial Board, American Journal of Physiology-Cell Physiology, https://journals.physiology.org/ajpcell/edboard. 2023
Guest Editor of Call for Papers: Mechanism Underlying Diversity in Cancer Cachexia, American Journal of Physiology-Cell Physiology, https://journals.physiology.org/ajpcell/mechanism-underlying-diversity-in-cancer-cachexia.