Dr Iain Dykes

Journal article

Adamova P, Powell AK, Dykes IM. 2024. Assessment of NanoString technology as a tool for profiling circulating miRNA in maternal blood during pregnancy Extracellular Vesicles and Circulating Nucleic Acids, 5 :571-596 DOI Author Url Publisher Url Public Url

Adamova P, Lotto RR, Powell AK, Dykes IM. 2022. Are there foetal extracellular vesicles in maternal blood? Prospects for diagnostic biomarker discovery Journal of Molecular Medicine, DOI Author Url Publisher Url Public Url

Fawcett SA, Al Kassas R, Dykes IM, Hughes AT, Ghali F, Ross K. 2022. A Time to Heal: MicroRNA and Circadian Dynamics in Cutaneous Wound Repair Clinical Science, 136 :579-597 DOI Author Url Publisher Url Public Url

Dykes IM, Ross K. 2021. Restoring the Final Frontier: Exosomal MicroRNA and Cutaneous Wound Repair Biomolecular Research Reports, 2022 DOI Author Url Publisher Url Public Url

Adams E, McCloy R, Jordan A, Falconer K, Dykes IM. 2021. Direct Reprogramming of Cardiac Fibroblasts to Repair the Injured Heart Journal of Cardiovascular Development and Disease, 8 DOI Author Url Publisher Url Public Url

Turton N, Swan R, Mahenthiralingam T, Pitts D, Dykes IM. 2019. The Functions of Long Non-Coding RNA during Embryonic Cardiovascular Development and Its Potential for Diagnosis and Treatment of Congenital Heart Disease Journal of Cardiovascular Development and Disease, 6 DOI Author Url Publisher Url Public Url

Dykes IM, Szumska D, Kuncheria L, Puliyadi R, Chen C, Papanayotou C, Lockstone H, Dubourg C, David V, Schneider JE, Keane TM, Adams DJ, Brown SDM, Mercier S, Odent S, Collignon J, Bhattacharya S. 2018. A Requirement for Zic2 in the Regulation of Nodal Expression Underlies the Establishment of Left-Sided Identity Scientific Reports, 8 DOI Author Url Publisher Url Public Url

Dykes IM, van Bueren KL, Scambler PJ. 2018. HIC2 regulates isoform switching during maturation of the cardiovascular system. Journal of Molecular and Cellular Cardiology, 114 :29-37 DOI Author Url Publisher Url Public Url

Dykes IM. 2017. Exosomes in Cardiovascular Medicine Cardiology and Therapy, 6 :225-237 DOI Author Url Publisher Url Public Url

Dykes IM, Emanueli C. 2017. Transcriptional and Post-transcriptional Gene Regulation by Long Non-coding RNA. Genomics, Proteomics and Bioinformatics, 15 :177-186 DOI Author Url Publisher Url Public Url

Dykes IM. 2014. Left right patterning, evolution and cardiac development Journal of Cardiovascular Development and Disease, 1 :52-72 DOI Author Url Publisher Url

Dykes IM, van Bueren KL, Ashmore RJ, Floss T, Wurst W, Szumska D, Bhattacharya S, Scambler PJ. 2014. HIC2 Is a Novel Dosage-Dependent Regulator of Cardiac Development Located Within the Distal 22q11 Deletion Syndrome Region CIRCULATION RESEARCH, 115 :23-31 DOI Author Url Publisher Url

GREENE NDE, COPP AJ, WARD A. 2012. Abstracts of papers presented at the 22nd Genetics Society's Mammalian Genetics and Development Workshop held at the Institute of Child Health, University College London on 17 November 2011 Genetics Research, 94 :49-55 DOI Publisher Url

Dykes IM, Tempest L, Lee S-I, Turner EE. 2011. Brn3a and Islet1 Act Epistatically to Regulate the Gene Expression Program of Sensory Differentiation JOURNAL OF NEUROSCIENCE, 31 :9789-9799 DOI Author Url Publisher Url

Dykes IM. 2010. A molecular study of regeneration in the CNS of the leech, Hirudo medicinalis.

Dykes IM, Lanier J, Eng SR, Turner EE. 2010. Brn3a regulates neuronal subtype specification in the trigeminal ganglion by promoting Runx expression during sensory differentiation NEURAL DEVELOPMENT, 5 DOI Author Url Publisher Url

Lanier J, Dykes IM, Nissen S, Eng SR, Turner EE. 2009. Brn3a Regulates the Transition from Neurogenesis to Terminal Differentiation and Represses Non-Neural Gene Expression in the Trigeminal Ganglion DEVELOPMENTAL DYNAMICS, 238 :3065-3079 DOI Author Url Publisher Url

Sun Y, Dykes IM, Liang X, Eng SR, Evans SM, Turner EE. 2008. A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs NATURE NEUROSCIENCE, 11 :1283-1293 DOI Author Url Publisher Url

Eng SR, Dykes IM, Lanier J, Fedtsova N, Turner EE. 2007. POU-domain factor Brn3a regulates both distinct and common programs of gene expression in the spinal and trigeminal sensory ganglia NEURAL DEVELOPMENT, 2 DOI Author Url Publisher Url

Dykes IM, Macagno ER. 2006. Molecular characterization and embryonic expression of innexins in the leech Hirudo medicinalis DEVELOPMENT GENES AND EVOLUTION, 216 :185-197 DOI Author Url Publisher Url

Dykes IM, Freeman FM, Bacon JP, Davies JA. 2004. Molecular basis of gap junctional communication in the CNS of the leech Hirudo medicinalis JOURNAL OF NEUROSCIENCE, 24 :886-894 DOI Author Url Publisher Url

Dykes IM, Davies JA. 2004. Cloning and expression of a leech complexin GENE EXPRESSION PATTERNS, 4 :93-97 DOI Author Url Publisher Url

Poster

Markham S, Watts G, Campbell A, Dykes I, Montgomery S. 2024. Can morphokinetics at the preimplantation stage be used to identify embryos that will later develop congenital heart disease? Fertility 2024 Conference

Adamova P, Lotto R, Powell A, Dykes I. 2022. Are there foetal extracellular vesicles in maternal blood? Prospects for diagnostic biomarker discovery UK EV Forum 2023, Fitzwilliam College, Cambridge

Adamova P, Lotto R, Powell A, Dykes I. 2022. Development of a non-invasive maternal blood test for congenital heart disease, Maternal Health Research Conference, Edge Hill University, Ormskirk

Dataset

Scambler P, Dykes I. 2011. Faculty Opinions recommendation of Zebrafish cardiac development requires a conserved secondary heart field. DOI Publisher Url

Scambler P, Dykes I. 2011. Faculty Opinions recommendation of Jerky/Earthbound facilitates cell-specific Wnt/Wingless signalling by modulating β-catenin-TCF activity. DOI Publisher Url

Scambler P, Dykes I. 2011. Faculty Opinions recommendation of Heartbeat regulates cardiogenesis by suppressing retinoic acid signaling via expression of miR-143. DOI Publisher Url

Scambler P, Dykes I. 2011. Faculty Opinions recommendation of Minor change, major difference: divergent functions of highly conserved cis-regulatory elements subsequent to whole genome duplication events. DOI Publisher Url

Conference presentation:

Poster presentation, Liverpool, Biologist at 100, A placental model to study extracellular vesicle communication between foetus and mother and their potential as prenatal biomarkers for Congenital Heart Disease.. 2025

Poster presentation, Edinburgh, Fertility 2024, Can morphokinetics at the preimplantation stage be used to identify embryos that will later develop congenital heart disease?. 2024

Poster presentation, Cambridge, UK Extracelllular Vesicles annual meeting 2023, Maternal blood biomarkers for congenital heart disease. 2023

Poster presentation, Edge Hill University, Maternal health conference, Development of a non-invasive maternal blood test for congenital heart disease. 2022

Poster presentation, LJMU, Institute for health research conference, Development of a non-invasive method for diagnosis of congenital heart disease based on analysis of embryonic-derived exosomes in the maternal circulation. 2019

Research Grants Awarded:

Duration of research project: 1 year, Grant value (£): 25000, Heart Research UK, Andrew Powell, Development of a non-invasive prenatal test for congenital heart disease using extracellular vesicles. 2025

Duration of research project: 6 months, Grant value (£): 10,000, Industrial Biotechnology Innovation Catalyst, Kehinde Ross, Illuminating Intercellular RNA transmission (External collaboration with Mast Group). 2025

Grant value (£): 63,000, Liverpool John Moores University (LJMU-VC Bicentenary PhD Scholarship), Modelling the placental barrier to facilitate identification of maternal blood biomarkers for congenital heart disease. 2024

Duration of research project: 3yrs, Grant value (£): 63000, Liverpool John Moores University Vice Chancellor's PhD studentship, Andrew Powell, Robyn Lotto, Claire Harper, Understanding foetal-maternal communication across the placenta to identify maternal blood biomarkers of congenital disease. 2024

Duration of research project: 3 months, Grant value (£): 1500, School of Pharmacy and Biomolecular sciences, LJMU (PBS Summer studentship scheme), Andrew Powell, EXTRACELLULAR VESICLE GLYCANS IN DIAGNOSTICS. 2023

Grant value (£): £378,000 (6x PhD students), Liverpool John Moores University (Thematic Doctoral Pathways), Part of a team of 12 academics led by Dr Kehinde Ross, Transformative Peptide Chemistry for RNA Nanotechnology. 2023

Duration of research project: 3 months, Grant value (£): 1750, School of Pharmacy and Biomolecular sciences, LJMU (PBS Summer studentship scheme), Fluorescent extracellular vesicles for diagnostics and therapeutics. 2022

Grant value (£): £63,000 (PhD student), Liverpool John Moores University (Institute of Health Research cross-faculty PhD scheme), Robyn Lotto, Andrew Powell, Identification of blood biomarkers for antenatal diagnosis of a common congenital heart defect, Tetralogy of Fallot.. 2020

Grant value (£): 10,000, Liverpool John Moores University (Faculty of Science seedcorn funding), Non-invasive methods for diagnosis of congenital heart disease. 2019

Duration of research project: 1 year, Grant value (£): £13,230, Newlife Charity for sick children, Exosome based signalling in the embryo and congenital heart disease. 2018

Teaching qualification:

Fellow of The Higher Education Academy (for work at LJMU). 2020

Staff and Educational Development Association Professional Development Framework Named Award In Learning, Teaching and Assessing. 2020

Postgraduate Certificate in Academic Practise (distinction). 2020

Fellow of The Higher Education Academy (for work at Bristol University). 2017

Associate Fellow of The Higher Education Academy (for work at Oxford University). 2016

Editorial boards:

Editorial board member, Biomolecular Research reports.

Review Editor, Frontiers in RNA Research - Non-coding RNA.